The role of adjuvant radiotherapy in the treatment of papillary tumors of the pineal region: some general considerations and a case-report

andrea lancia, gianluca ingrosso, riccardo santoni


Background:  Papillary Tumor of the Pineal Region (PTPR) is a recently defined tumor entity. Its clinical course is characterized by frequent local recurrence.  Guidelines for treatment protocols, and the role of radiotherapy are still being investigated.

Case: We report the case of a 27-year-old woman who was diagnosed with PTPR and underwent surgery and adjuvant conformal radiotherapy on the gross residual tumor to a total dose of 59.4 Gy (33 x 1.8 Gy).

Discussion: after a follow-up of 41 months, we obtained a complete response to the treatment, according to the RECIST criteria. Radiation treatment was well tolerated without acute and late side effects. The neurological symptoms which were documented at the diagnosis and after the surgical procedure, have not been recorded at last follow-up.

Conclusion: Formal consensus for managing patients with a diagnosis of PTPR are nonexistent. Despite surgery, this tumor has a tendency to recur. Radiotherapy could have a role in the adjuvant setting, and need to be investigated on a multi-centre study with a long follow-up.

Klíčová slova

papillary tumors pineal region; radiotherapy

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