The mitogen-activated protein kinase (MAPK) pathway is regulated by long non-coding RNAs.

Soudeh Ghafouri-Fard

Abstrakt


Background: The mitogen-activated protein kinase (MAPK) pathway contributes in regulation of many cellular functions such as cell proliferation and differentiation, mobility and apoptosis. This pathway is itself regulated by several outside signals as well as lateral signals from other pathways which construct a complex network. Long non-coding RNAs (lncRNAs) as principal modulators of gene expression at transcriptional and post-transcriptional levels also regulate this pathway.

Material and Methods: We searched PubMed database by key words lncRNA and MAPK pathway. Considering the role of this pathway in the pathogenesis of several cancers, alterations in lncRNA expression lead to changes in MAPK pathway resulting in inhibition of apoptosis and induction of cell proliferation and migration. Based on the availability of certain anticancer drugs that modulate this pathway, identification of lncRNAs that affect this pathway would help in establishment of effective therapies.


Klíčová slova


lncRNA; MAPK pathway; cancer

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