Down-regulation of TSGA10, AURKC, OIP5 and AKAP4 genes by Lactobacillus rhamnosus GG and Lactobacillus crispatus SJ-3C-US supernatants in HeLa cell line

Zahra Nouri, Nadia Neyazi, Mohammad Hossein Modarressi, Fatemeh Karami, Atieh Abedin-Do, Zahra Taherian-Esfahani, Soudeh Ghafouri-Fard, Elahe Motevaseli

Abstrakt


Background : Cancer testis antigens (CTAs) are considered as cancer biomarkers due to highly specific expression in malignancies. Their specific expression has made them potential targets for the diagnosis, prognosis and treatment of cancer in recent years. Lactobacilli are a group of probiotics with anti-cancer features.

Aims: We investigated the effect of Lactobacillus rhamnosus GG supernatant (LRS) and Lactobacillus crispatus SJ-3C-US supernatant (LCS) on expression of four CTAs ( TSGA10, AURKC, OIP5 and AKAP4 ) in the HeLa cell line. 

Results: LRS and LCS inhibited HeLa cell growth after 24 hours. Expressions of all CTAs were down-regulated after treatment with both supernatants.

Conclusion: This study demonstrated the role of lactobacilli in down-regulation of CTAs genes. These expression changes may be involved in the anticancer effects of these lactobacilli .


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