Association of TNF-α -308G>A Polymorphism with Susceptibility to Cervical Cancer and Breast Cancer: a Systematic Review and Meta-Analysis

Meraj Farbod, Mojgan Karimi-Zarchi, Neda Seifi-Shalamzari, Naeimeh Heiranizadeh, Mohammad Javad Akbarian-Bafghi, Mohammad Hossein Jarahzadeh, Hossein Neamatzadeh


Background: Several previous studies were carried out on the association of TNF-α -308G>A with cervical and breast cancer risk. However, their conclusions were not consistent. Thus, we performed a comprehensive meta-analysis to evaluate the association more preciously from all eligible case-control studies.

Methods: We searched systematically PubMed, Google Scholar and the Cochrane Library databases to identify relevant studies up to February 01, 2019. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects model.

Results: A total of 40 case-control studies including 20 studies on cervical cancer and 20 studies on breast cancer were selected in this meta-analysis. The pooled results showed that the TNF-α -308G>A polymorphism was significantly associated with increased risk of cervical cancer (A vs. G: OR = 1.277, 95% CI = 1.104-1.477, P = 0.001; AA vs. GG: OR = 1.333, 95% CI = 1.062-1.674, P = 0.013; AG vs. GG: OR = 1.307, 95% CI = 1.064-1.605, P = 0.011; and AA+AG vs. GG: OR = 1.324, 95% CI = 1.104-1.587, P = 0.002) and breast cancer (AA vs. AG+GG: OR=0.094, 95% CI 0.058-0.152, p≤0.001). In the stratified analyses by ethnicity, the TNF-α -308G>A polymorphism was significantly associated with risk cervical cancer (in Caucasians and African) and breast cancer (Caucasians and Asians).

Conclusions: Our findings showed that TNF-α -308G>A polymorphism may be a risk factor for cervical cancer and breast cancer in overall and by ethnicity.

Klíčová slova

Cervical Cancer, Breast Cancer, TNF-α Gene, Polymorphism, Meta-Analysis

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