Association of MTHFR 677C>T, 1298A>C and MTR 2756A>G Polymorphisms with Risk of Retinoblastoma in the Iranian Children: A Case-Control Study

Mohsen Gohari, Jamal Jafari-Nedooshan, Mohammad Javad Akbarian-Bafghi, Majid Morovati-Sharifabad, Seyed Reza Mirjalili, Hossein Neamatzadeh, SA Dastgheib

Abstrakt


Background: The MTHFR 677C>T, 1298A>C and MTR 2756A>G polymorphisms have been investigated in several different cancer types. However, the role of these polymorphisms in development of retinoblastoma remains unclear. This case-control study was conducted to analyses the association of MTHFR 677C>T, 1298A>C and MTR 2756A>G polymorphisms with retinoblastoma in Iranian Children.

Methods: The MTHFR 677C>T, 1298A>C and MTR 2756A>G polymorphisms in 66 patients with retinoblastoma and 99 age and gender matched healthy controls were detected on the ABI PRISMs 7500 Real-Time PCR System. The association between these polymorphism and retinoblastoma risk was analyzed by odds ratio (OR) with 95% confidence interval (CI).

Results: Our results showed a significant association between MTR 2756A>G polymorphism and retinoblastoma risk. In MTR 2756A>G polymorphism, AG (39.4%) and GG (9.1%) genotype frequencies in cases were found to be higher in comparison to controls showing significant difference (p < 0.05). However, no significant difference was observed in allelic or genotypic frequencies for both MTHFR 677C>T and 1298A>C polymorphisms in retinoblastoma patients and controls (p > 0.05). 

Conclusions: Our results suggested that MTR 2756A>G polymorphism might be associated with increased risk of retinoblastoma in the Iranian children. However, the results showed that the MTHFR 677C>T and 1298A>C polymorphisms not significantly associated with increased risk of retinoblastoma in the Iranian children.


Klíčová slova


Retinoblastoma; Childhood; MTHFR gene; MTR gene; Polymorphism

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