bP21-associated ncRNA DNA damage –activated expression in bladder cancer

Mohammad Taheri

Abstrakt


Background: Long non-coding RNAs (lncRNAs) have been recently the foci of attention of cancer researchers for their diverse roles in the carcinogenesis process. The P21 associated ncRNA DNA damage activated (PANDA) has especial situation in this regard due to its adjacency to the CDKN1A locus. It is involved in the regulation of DNA damage response, cell senescence and proliferation.

Material and methods: In the current study, we assessed expression of this lncRNA in bladder cancer tissues, adjacent non-cancerous tissues (ANCTs) and normal bladder samples.

Results: No significant difference has been detected in PANDA expression either between tumor tissues and ANCTs (expression ratio=1.75, P=0.11) or between tumor tissues and normal tissues (expression ratio=2.72, P=0.57). Expression level of this lncRNA was not associated with any of demographic or clinical data of patients or cancer-associated risk factors such as cigarette smoking or opium addiction.

Conclusion: Consequently, the current study implies that PANDA is not involved in the pathogenesis of bladder cancer.


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