Expression analysis of the long non-coding RNA LINC01433 in lung cancer

Mohammad Taheri, Farbod Esfandi, Soudeh Ghafouri-fard, Zohreh Niazi, Ehsan Garazhian, Zabih Mir Hassani

Abstrakt


 

BACKGROUND: Long non-coding RNAs (lncRNAs) have been shown to influence the pathogenic course of lung cancer. However, the contribution of LINC01433 lncRNA in this type of cancer in Iranian patients is not clear.

AIMs: In the current project, we evaluated expression of LINC01433 in 42 non-small cell lung cancer samples and their paired non-tumoral tissues using real time PCR method.

RESULTS: There was no significant difference in the expression of LINC01433 between tumoral and non-tumoral tissues (expression ratio=0.67, P value=0.42). Expression of this lncRNA was not associated with any of clinical and demographic data including age, gender, smoking history, stage or cancer subtype.

CONCLUSIONS: Consequently, this lncRNA is not a possible contributor to lung cancer in Iranian patients.


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