A new approach in DCE MRI data analysis for differentiating benign and malignant breast lesion.

Petra Hnilicová, Tomasz Jaunky, Eva Baranovičová, Eva Hečková, Michal Bittšanský, Dušan Dobrota

Abstrakt


Dynamic contrast enhanced MRI (DCE MRI) is able to reflect changes in vascularity, vessel permeability, and extracellular diffusion space of tissues. The goal of this study was to investigate the use of DCE MRI to differentiate benign and malignant breast lesions.

From a database, 5 patients were randomly chosen with malignant and 5 with benign lesions. All patients underwent measurement in a 3T MR scanner using a breast coil. A series of T1-weighted MRI were performed using an intravenously delivered contrast agent. Seventeen post-contrast sets were then acquired within a timeframe of 13 seconds. All DCE MRI data were evaluated using the JIM image analysis package. We observed changes in signal intensity over the acquisition time - curves of dynamic contrast enhancement.

We investigated parts of the curves with the largest increase in signal intensity during the timeframe. For further comparison, we used the values of the highest signal intensity increases between the timeframes. Analysis of these results led to the proposal that the threshold between benign and malignant lesion, had a relative value of 100. Furthermore, there was significant difference between these two lesion types.



Klíčová slova


Breast Cancer; Magnetic Resonance Imaging; Extravasation of Contrast Media

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